Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Nuria Tubio-Santamaria, Ashok Kumar Jayavelu, Tina M Schnoeder, Theresa Eifert, Chen-Jen Hsu, Florian Perner, Qirui Zhang, Daniela V Wenge, Fynn M Hansen, Joana M Kirkpatrick, Nidhi Jyotsana, Steven W Lane, Björn von Eyss, Aniruddha J Despande, Michael WM Kühn, Juerg Schwaller, Clemens Cammann, Ulrike Seifert, Frederic Ebstein, Elke Krüger, Andreas Hochhaus, Michael Heuser, Alessandro Ori, Matthias Mann, Scott A Armstrong, Florian H Heidel
Mol Cancer 2023 Dec4; 22(1):196; PMID: 38049829
Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia
Theresa Eifert, Chen-Jen Hsu, Alicia L Becker, Sarah Graessle, Arik Horne, Franziska Bemmann, Qirui Zhang, Michael Heuser, Valeri Vasioukhin, Sebastian Scholl, Andreas Hochhaus, Florian Siegerist, Nicole Endlich, Lars Bullinger, Steven W Lane, Simon Haas, Tina M Schnoeder, Florian H Heidel
Leukemia 2023 Oct ;37(10):2027-2035; PMID: 37587260
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal
Tina M Schnöder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth N. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H Heidel
Blood 2022 Feb 17;139(7):1080-1097; PMID: 34695195
YBX1 mediates translation of oncogenic transcripts to control cell competition in AML
Florian Perner, Tina M Schnöder, Yijun Xiong, Ashok Kumar Jayavelu, Nomusa Mashamba, Nuria Tubio Santamaria, Nicolas Huber, Kristina Todorova, Charles Hatton, Birgit Perner, Theresa Eifert, Ciara Murphy, Maximilian Hartmann, Jessica I. Höll, Nicolas Schröder, Sabine Brandt, Andreas Hochhaus, Peter R. Mertens, Matthias Mann, Scott A. Armstrong, Anna Mandinova, Florian H Heidel
Leukemia 2022 Feb;36(2):426-437; PMID: 34465866
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms
Ashok Kumar Jayavelu*, Tina M Schnöder*, Florian Perner, Carolin Herzog, Arno Meiler, Gurumoorthy Krishnamoorthy, Nicolas Huber, Juliane Mohr, Bärbel Edelmann-Stephan, Rebecca Austin, Sabine Brandt, Francesca Palandri, Nicolas Schröder, Berend Isermann, Frank Edlich, Amit U Sinha, Martin Ungelenk, Christian A Hübner, Robert Zeiser, Susann Rahmig, Claudia Waskow, Iain Coldham, Thomas Ernst, Andreas Hochhaus, Stefanie Jilg, Philipp J Jost, Ann Mullally, Lars Bullinger, Peter R Mertens, Steven W Lane, Matthias Mann, Florian H Heidel
Nature 2020 Dec;588(7836):157-163; PMID: 33239784
* contributed equally
PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia
Maria Saliakoura, Matteo Rossi Sebastiano, Chiara Pozzato, Florian H Heidel, Tina M Schnöder , Spasenija Savic Prince, Lukas Bubendorf , Paolo Pinton, Ralph A Schmid, Johanna Baumgartner, Stefan Freigang, Sabina A Berezowska, Alessandro Rimessi, Georgia Konstantinidou
Nat Cell Biol. 2020 Oct 19; PMID: 33077911
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
Therese Vu , Jasmin Straube, Amy H Porter, Megan Bywater, Axia Song, Victoria Ling, Leanne Cooper, Gabor Pali, Claudia Bruedigam, Sebastien Jacquelin, Joanne Green, Graham Magor, Andrew Perkins, Alistair M Chalk, Carl R Walkley, Florian H Heidel, Pamela Mukhopadhyay, Nicole Cloonan, Stefan Gröschel, Jan-Philipp Mallm, Stefan Fröhling, Claudia Scholl, Steven W Lane
Nat Comm. 2020 Jun 15;11(1):3021; PMID: 32541670
Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations
Rebecca J Austin, Jasmin Straube, Claudia Bruedigam, Gabor Pali, Sebastien Jacquelin, Therese Vu, Joanne Green, Julius Gräsel, Lianne Lansink, Leanne Cooper 1 , Shin-Jye Lee, Nien-Tsu Chen, Chung-Wei Lee, Ashraful Haque, Florian H Heidel, Richard D'Andrea, Geoff R Hill, Ann Mullally, Michael D Milsom, Megan Bywater, Steven W Lane
Leukemia. 2020 Apr;34(4):1075-1089; PMID: 31732720
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
Sibylle Cocciardi, Anna Dolnik, Silke Kapp-Schwoerer, Frank G Rücker, Susanne Lux, Tamara J Blätte, Sabrina Skambraks, Jan Krönke, Florian H Heidel, Tina M Schnöder, Andrea Corbacioglu, Verena I Gaidzik, Peter Paschka, Veronica Teleanu, Gudrun Göhring, Felicitas Thol, Michael Heuser, Arnold Ganser, Daniela Weber, Eric Sträng, Hans A Kestler, Hartmut Döhner, Lars Bullinger, Konstanze Döhner
Nat Commun. 2019 May 2;10(1):2031; PMID: 31048683
The cell fate determinant Scribble is required for maintenance of hematopoietic stem cell function
Mohr J, Dash BP, Schnoeder TM, Wolleschak D, Herzog C, Tubio Santamaria N, Weinert S, Godavarthy S, Zanetti C, Naumann M, Hartleben B, Huber TB, Krause DS, Kähne T, Bullinger L, Heidel FH
Leukemia 2018 May;32(5):1211-1221; PMID: 29467485
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms
Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R
Sci Transl Med. 2018 Feb 21;10(429); PMID: 29467301
JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation
Edelmann B, Gupta N, Schnöder TM, Oelschlegel AM, Shahzad K, Goldschmidt J, Philipsen L, Weinert S, Ghosh A, Saalfeld FC, Nimmagadda SC, Müller P, Braun-Dullaeus RC, Mohr J, Wolleschak D, Kliche S, Amthauer H, Heidel FH, Schraven B, Isermann B, Müller A, Fischer T
J Clin Invest. 2018 Oct 1;128(10):4359-4371; PMID: 30024857
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schnöder TM, Brunner-Weinzierl MC, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH and Isermann B
Nature Commun. 2017 Aug 21;8(1):311; PMID: 28827518
Gain of function in Jak2 V617F-positive T-cells
G Nishanth, D Wolleschak, C Fahldieck, T Fischer, A Mullally, F Perner, T M Schnöder, S Just, F H Heidel, D Schlüter
Leukemia. 2017 Apr;31(4):1000-1003; PMID: 28074070
Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo
Arreba-Tutusaus P, Mack TS, Bullinger L, Schnoeder TM, Polanetzki A, Weinert S, Ballaschk A, Wang Z, Deshpande AJ, Armstrong SA, Döhner K, Fischer T, Heidel FH
Leukemia. 2016 May;30(5):1220-5; PMID: 26487272
Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
Perner F, Schnöder TM, Ranjan S, Wolleschak D, Ebert C, Pils MC, Frey S, Polanetzki A, Fahldieck C, Schönborn U, Schraven B, Isermann B, Fischer T, Heidel FH
Leukemia. 2016 30: 991-995; PMID: 26242463
Epo-induced erythroid maturation is dependent on Plcg1 signaling
Schnöder T, Arreba-Tutusaus P, Griehl I, Bullinger L, Buschbeck, M, Lane SW, Döhner K, Plass C, Lipka DB, Heidel FH* and Fischer T*
Cell Death Differ. 2015 Jun;22(6):974-85; PMID: 25394487
Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy
Bruedigam C, Otzen Bagger F, Heidel FH, Paine Kuhn C, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, Moore AS, Lock RB, Bullinger L, Hill GR, Armstrong SA, Williams DA, Lane SW
Cell Stem Cell. 2014 Dec 4;15(6):775-90; PMID: 25479751
The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML
Heidel FH, Bullinger L, Arreba-Tutusaus P, Wang Z, Gaebel J, Hirt C, Niederwieser D, Lane SW, Dohner K Vasioukhin V, Fischer T and Armstrong SA
J Exp Med. 2013 Jan 14;210(1):15-22; PMID: 23277453
Genetic and Pharmacologic Inhibition of b-Catenin Targets Imatinib Resistant Leukemia Stem Cells in CML
Heidel FH, Bullinger L, Feng Z, Wang Z, Neff TA, Stein L, Kalaitzidis D, Lane SW and Armstrong SA
Cell Stem Cell. 2012 Apr 6;10(4):412-24; PMID: 22482506